“Compilation and Analysis of Amyloid-Binding Ligands’ Dissociation Constants Reveals Variations in Binding Affinities and the Role of Hydrophobic Effects and Polar Interactions”

https://pubmed.ncbi.nlm.nih.gov/38116736

This study compiles and analyzes a large database of amyloid-binding ligands and their dissociation constants, finding variations in binding affinities and suggesting that hydrophobic effects and polar interactions play a role in ligand binding to amyloid fibrils associated with neurodegenerative diseases.