Exosomal miR-143-5p and miR-342-5p from injured alveolar type II cells inhibit fatty acid synthesis and contribute to injury in idiopathic pulmonary fibrosis, but antifibrotic drugs pirfenidone and nintedanib reverse these effects.

https://pubmed.ncbi.nlm.nih.gov/38117249

In idiopathic pulmonary fibrosis, exosomal miR-143-5p and miR-342-5p from injured alveolar type II cells inhibit fatty acid synthesis and contribute to injury, but antifibrotic drugs pirfenidone and nintedanib reverse these effects.