“EGF-Induced EGFR Slowdown Requires Higher-Order Oligomerization Mediated by Tyrosine Kinase Domain”

https://pubmed.ncbi.nlm.nih.gov/38117650

EGFR dimerization driven by the extracellular region alone is not sufficient for the EGF-induced EGFR slowdown, which requires higher-order oligomerization mediated by the intracellular tyrosine kinase domain in an active conformation.