“Genetic Factors in Type 1 Diabetes: A Review of MHC and Non-MHC Loci and Their Impact on Gene Regulation”

https://pubmed.ncbi.nlm.nih.gov/38117927

The abstract reports on the genetic factors of Type 1 Diabetes, estimating that about 50% of the risk is attributed to genes in the MHC region, including HLA loci, and over 90 non-MHC loci have been identified, with most variants affecting gene regulation rather than protein structure, and further research is needed to understand the genetic and environmental underpinnings of distinct phenotypes within the disease spectrum.