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https://pubmed.ncbi.nlm.nih.gov/38091482
The abstract reports the use of trapped-ion-mobility spectrometry coupled to time-of-flight mass spectrometry (TIMS-TOF MS) to characterize the phosphorylation status of the gastric inhibitory polypeptide receptor (GIPR), identifying eight serine residues that are phosphorylated, and revealing that the synthetic agonist tirzepatide enhances phosphorylation at a unique site compared to the native agonist GIP.