https://pubmed.ncbi.nlm.nih.gov/38117890
The COVID-19 pandemic led to increased political homophily in nonkin relationships and amplified political echo chambers through remote communication.
https://pubmed.ncbi.nlm.nih.gov/38117889
This study describes a new method for efficiently synthesizing unnatural peptides using cobalt-catalyzed diastereoselective umpolung hydrogenation, which is versatile, efficient, and does not cause racemization or epimerization.
https://pubmed.ncbi.nlm.nih.gov/38117888
The abstract reports on a study estimating the global transfer of kinetic energy in the ocean across different scales, finding that upscale transfer peaks at 300 gigawatts and is primarily deposited at a scale four times larger, with a self-similar seasonal cycle.
https://pubmed.ncbi.nlm.nih.gov/38117886
This study used haploid genetic screening to identify Dyrk1a as a repressor of totipotency in trophectoderm specification, and found that Dyrk1a-null embryonic stem cells exhibit totipotent developmental abilities.
https://pubmed.ncbi.nlm.nih.gov/38117884
Researchers reconstituted the serine protease framework in Drosophila and identified a network of 10 proteases that mediate melanization and Toll pathway activation, revealing the specific order of proteolytic activation events.
https://pubmed.ncbi.nlm.nih.gov/38117883
This study reports the development of an Ir/Zn-cocatalyzed atroposelective [2+2+2] cycloaddition of 1,6-diynes and ynamines to construct various functionalized C─N axially chiral indoles and pyrroles in high yields, chemoselectivities, and enantioselectivities, providing a more efficient and reliable alternative to previous methods for asymmetric alkyne [2+2+2] cyclotrimerization.
https://pubmed.ncbi.nlm.nih.gov/38117882
Observational studies of COVID-19 booster effectiveness show variable protection against infection but strong protection against severe disease, with test-negative design offering statistical advantages.