https://pubmed.ncbi.nlm.nih.gov/38117487
This study identifies meaningful within-patient score change thresholds for the Psoriasis Symptoms and Signs Diary, which can help evaluate treatment efficacy in psoriasis clinical trials.
https://pubmed.ncbi.nlm.nih.gov/38117487
This study identifies meaningful within-patient score change thresholds for the Psoriasis Symptoms and Signs Diary, which can help evaluate treatment efficacy in psoriasis clinical trials.
https://pubmed.ncbi.nlm.nih.gov/38117485
This case report details a patient with antisynthetase syndrome who was treated with ruxolitinib for refractory angioedema-like panniculitis associated with PL-12 antisynthetase syndrome, resulting in significant improvement.
https://pubmed.ncbi.nlm.nih.gov/38117484
This study found that IDH-mutant gliomas undergo epigenetic evolution towards an IDH-wildtype-like phenotype in response to treatment, which is associated with histological progression and changes in the tumor microenvironment.
https://pubmed.ncbi.nlm.nih.gov/38117483
The study found that switching from ticagrelor to clopidogrel in stabilized myocardial infarction patients with high ischemic risk did not result in significantly different ischemic or bleeding outcomes compared to continuing ticagrelor-based dual antiplatelet therapy.
https://pubmed.ncbi.nlm.nih.gov/38117482
New drug DRP-104, a prodrug of DON, shows potential in treating pancreatic cancer by targeting tumor metabolism and glutamine dependency, with tumors adapting through the MEK/ERK pathway and asparagine synthesis, suggesting combined therapy with MEK inhibitor trametinib and asparaginase could be effective.
https://pubmed.ncbi.nlm.nih.gov/38117481
The evolution of the unique vanillylamine synthase enzyme (pAMT) in chili peppers, responsible for the synthesis of pungent capsaicinoids, involved duplication of a chloroplastic GABA-T ancestor, loss of the plastid transit signal, and specific translocation during Capsicum divergence, as well as increased catalytic efficiency and transcriptional changes.
https://pubmed.ncbi.nlm.nih.gov/38117480
The abstract reports a study that found rapid consumption of injected dihydrogen (H2) in a shallow aquifer by various microbes, leading to temporary changes in the groundwater microbiome and geochemical conditions.
https://pubmed.ncbi.nlm.nih.gov/38117479
This study utilizes small-angle neutron scattering and ultra-small-angle neutron scattering to investigate the structure of collagen-nanocellulose hydrogels, revealing that nanocellulose fibers expand and increase the homogeneity of the collagen network without affecting the inherent properties of either polymer, and that cells cultured in these hydrogels remodel the network without significantly altering its architecture.
https://pubmed.ncbi.nlm.nih.gov/38117478
This study compares enzyme and nonenzyme methods for uric acid detection using a calcium fluoride/manganese dioxide nanocomposite with dual-enzyme activity, demonstrating the good selectivity of the enzyme method and the fast response of the nonenzyme method, and their potential for accurately detecting uric acid in human serum.