https://pubmed.ncbi.nlm.nih.gov/38116716
In T3 supraglottic cancers treated with IMRT, increasing primary tumor volume is associated with worse overall and disease-free survival.
https://pubmed.ncbi.nlm.nih.gov/38116715
Infusion reactions to adeno-associated virus (AAV) gene therapy, caused by Toll-like receptor activation and pro-inflammatory cytokines, present a significant challenge to the safety and efficacy of AAV-based gene therapy, with current treatment options being inadequate and in need of further research.
https://pubmed.ncbi.nlm.nih.gov/38116714
The layer-by-layer assembly technology, which forms self-assembled films of complementary polyelectrolytes or biomolecules, has recently seen developments in its use as 2D or 3D objects for applications in drug delivery and tissue engineering, such as vaccinology, 3D biomimetic tissue models, and bone and cardiovascular tissue engineering.
https://pubmed.ncbi.nlm.nih.gov/38116713
The Ser38-His93-Asn91 triad in the Y93H variant of HCV NS5A allows it to form a dimer and conduct RNA replication even in the absence of NS5A inhibitors, thereby conferring resistance to these inhibitors.
https://pubmed.ncbi.nlm.nih.gov/38116712
The abstract suggests that individuals with Long COVID may benefit from evaluation for underlying hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders, as proper diagnosis and management of these conditions could potentially improve their symptoms and overall health outcomes.
https://pubmed.ncbi.nlm.nih.gov/38116707
This study introduces a flexible hydrovoltaic device with highly sensitive ion-sensing abilities across a wide concentration range, utilizing silk fibroin-regulated nanochannels, which exhibits superior sensitivity and potential for wearable sweat and environmental ion monitoring.