https://pubmed.ncbi.nlm.nih.gov/38116556
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https://pubmed.ncbi.nlm.nih.gov/38116554
This study describes the design and expression of a recombinant chimeric spike protein from SARS-CoV-2 in E. coli, which induces a strong immune response and produces neutralizing antibodies against various virus serotypes, including the omicron variant, suggesting its potential as a subunit vaccine candidate.
https://pubmed.ncbi.nlm.nih.gov/38116552
The study found that hyaluronic acid-modified liposomes for Ursolic Acid-targeted delivery (HA-Lipo/UA) effectively target and inhibit the growth of lung cancer cells through p53/ARTS-mediated mitochondrial apoptosis.
https://pubmed.ncbi.nlm.nih.gov/38116550
This study found that a majority of consumers are willing to pay for pharmacist counselling services in community pharmacies, with a higher willingness to pay for more extensive counselling, and that factors such as income, age, duration of illness, internet usage, and perceived need for a community pharmacist influence their willingness to pay.
https://pubmed.ncbi.nlm.nih.gov/38116549
A newly synthesized zinc-based metal-organic framework shows potential as a low-toxicity drug carrier for tumor treatment, exhibiting pH-sensitive drug release and high antitumor activity against HepG2 cells.
https://pubmed.ncbi.nlm.nih.gov/38116548
This randomized clinical trial found that using a high-dose pulse therapy of methylprednisolone in patients with mild to moderate ARDS due to COVID-19 did not improve in-hospital clinical outcomes and was associated with a higher risk of bacterial pneumonia.
https://pubmed.ncbi.nlm.nih.gov/38116547
The methanol extract of the brown alga Sargassum boveanum from the Persian Gulf shows potential as a new source for antidiabetic and antibacterial compounds, as demonstrated by its in vitro α-glucosidase inhibition and antibacterial activities, as well as its in vivo lowering of blood glucose levels in streptozotocin-induced diabetic rats.