https://pubmed.ncbi.nlm.nih.gov/38091296
A nanocellulose and gelatin-based hydrogel has been engineered to mimic the nonlinear mechanical behavior of biological fibrous networks.
https://pubmed.ncbi.nlm.nih.gov/38091295
Chemical fixation with PFA in MNT-1 cells causes protein clustering, disrupts melanosome distribution, and partially alters protein secondary structure, as revealed by SE-ADM and Raman imaging.
https://pubmed.ncbi.nlm.nih.gov/38091294
The study finds that myosin-binding protein H-like (MyBP-HL) regulates the distribution and function of myosin-binding protein C (cMyBP-C) in atrial cardiomyocytes, affecting the kinetics of sarcomere relaxation.
https://pubmed.ncbi.nlm.nih.gov/38091293
Researchers have designed potent and specific proteasome inhibitors targeting β2, based on the structure of the endogenous inhibitor PI31/Fub1, which may provide a new treatment approach for multiple myeloma and enhance existing therapies.
https://pubmed.ncbi.nlm.nih.gov/38091292
The abstract reports that metabotropic glutamate receptor 1α (mGluR1α)-mediated plasticity at granule cell to somatostatin-expressing interneuron synapses in the mouse dentate gyrus is critical for object location memory.
https://pubmed.ncbi.nlm.nih.gov/38091290
Large Language Models GPT-3/text-davinci-002, GPT-3/text-davinci-003, and ChatGPT show variable accuracy, instability, and a yes-response bias in identifying grammatical and ungrammatical word patterns, differing significantly from human performance.
https://pubmed.ncbi.nlm.nih.gov/38091289
This study identifies the interaction between intraneuronal beta-amyloid and the mitochondrial protease LONP1 as a key factor in mitochondrial dysfunction in Alzheimer’s disease, highlighting a potential target for therapeutic intervention.
https://pubmed.ncbi.nlm.nih.gov/38091288
The provided scientific abstract discusses a study on rate-induced tipping (R-tipping) in complex, high-dimensional ecological networks, introducing a global perspective on the probability of R-tipping and finding a scaling law to explain its real-world implications, revealing that even slow parameter changes can lead to catastrophic consequences, and merely slowing down the parameter drift may not always be effective in mitigating environmental changes.
https://pubmed.ncbi.nlm.nih.gov/38091286
This study finds that self-sustained oscillations in an exoplanet’s atmospheric ozone chemistry, driven by nonlinear photochemical systems and biological nitrogen fixation, could be a unique class of biosignature, detectable over multidecadal timescales.