https://pubmed.ncbi.nlm.nih.gov/38114772
Glycan receptor-targeted gemcitabine-loaded nanoparticles show enhanced accumulation, retention, and anticancer efficacy in a benzo[a]pyrene-induced lung cancer model.
https://pubmed.ncbi.nlm.nih.gov/38114770
This study discovers and characterizes genes that naturally resist the antibiotic capreomycin, specifically focusing on the gene cph which encodes a phosphotransferase, and reveals how certain proteins in cluster I confer resistance to capreomycin.
https://pubmed.ncbi.nlm.nih.gov/38114769
This study found that, in patients with both metabolic dysfunction-associated fatty liver disease and diabetes mellitus, use of sodium-glucose cotransporter 2 inhibitors was associated with greater improvement in fatty liver index compared to dipeptidyl peptidase 4 inhibitors.
https://pubmed.ncbi.nlm.nih.gov/38114767
This study establishes new identifiability conditions for restricted latent class models with multiclass response data and proposes a Bayesian framework for parameter estimation, with applications to polytomous and nominal response data.
https://pubmed.ncbi.nlm.nih.gov/38114766
The review discusses the correlation between the use of anthelmintic drugs in human and animal populations and the development of anthelmintic resistance in soil-transmitted helminths within a One-Health framework.
https://pubmed.ncbi.nlm.nih.gov/38114763
The study found that extending hairpin activators enhances CRISPR/Cas12a activation for transcription factor detection, while intact hairpins without PAM sequences are inactive, and applied this discovery to develop a CRISPR/Cas12a-based strategy for detecting NF-ĸB p50 with a linear range of 0.8 – 2000.0 pM and a LOD of 0.5 pM.