https://pubmed.ncbi.nlm.nih.gov/38113273
A specific isoform of LEF1, ΔN LEF1, restricts EBV reactivation to maintain viral latency through repressive chromatin remodeling of critical lytic cycle factors.
https://pubmed.ncbi.nlm.nih.gov/38113272
This study presents a simple and sensitive method for detecting protein kinase activity using nanoimpact electrochemistry and silver nanoparticles, offering a label-free, cost-effective, and selective alternative to existing methods, and enabling real-time monitoring of kinase-catalyzed phosphorylation processes.
https://pubmed.ncbi.nlm.nih.gov/38113271
GPATCH4 is a stimulatory cofactor of DHX15 that regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and -independent manners, affecting protein synthesis and cell growth.
https://pubmed.ncbi.nlm.nih.gov/38113267
This study used polygenic risk scores as proxies for COVID-19 severity in three large biobanks to identify associations between pre-existing conditions and COVID-19 severity, revealing significant relationships with obesity, metabolic disorders, and cardiovascular conditions, and highlighting the potential value of using PRS when actual outcome data may be limited.